Methionine in combination with lipotropic has been proposed to treat endometriosis which is a condition where endometrial tissue patches from the lining of the uterus grows outside of the uterus. Methionine is a nutrient that is especially important and beneficial for those who are suffering from the dominance of estrogen where estrogen in the person’s body becomes highly excessive as compared to the progesterone, its opposing hormone. It is believed that the nutrient helps in expediting the excess estrogen removal from the liver.
Methionine is a lipotrope and an antioxidant which means it helps in removing fat from our liver. Methionine helps in contributing to the protein’s hydrophobicity. Methionine is controlling the level of helpful sulfur containing compounds found in our body. These compounds are vital in our defense against toxic compounds such as the heavy metals in our liver. Methionine is helping in the reduction of the levels of histamine the amino acids that help in controlling the blood vessels’ dilation and it also influence the function of the brain.
Dietary Sources of Methionine
Sesame seeds, fish, Brazil nuts, meat and other plant seeds are great sources of methionine in high levels. Cereal grains also have methionine. Most of the vegetables and fruits contain only little amount of it. Methionine is also found in low levels with most legumes. The complement of cereal (containing methionine) with legumes (containing lysine) provides the complete protein which is a classic combination that is found around the world such as in beans and rice and other combinations that are discussed there. Sesame seeds like hummus provide the methionine in cuisines of the Arabs.
Sesame seeds used in cuisines such as in Indian cuisines and in the form of tahini as used in Arab cuisines help in providing the necessary protein in vegan and vegetarian diets. For example, sesame seeds and hummus are combined w/ chickpeas. Meat, dairy products and fish are excellent sources of Methionine. You can also find from vegetables and fruits the L-Methionine but it’s not abundant. Only small amounts of the L-methionine occur in fermented foods, vegetable juices and vegetables. Whole grains is a good source of methionine especially for vegetarians.
Requirements of Amino acid vary with your body weight. Supplements for L-methionine should only be taken with the recommendation from your physician. According to FAO or the Food & Agriculture Organitation of United States as well as with World Health Organization or WHO recommends that 13 mg per kilo or about a gram of L-methionine a day for adults is recommended. During supplementation of methionine, you should also include the intake of cystine, taurine, B6, folic acid and other sulfur containing amino acids.
The abundance of the ß-chain of ß –conglycinin causes the deficiency of Methionine. It is the seed storate protein that does not have methionine. The deficiency of Methionine is associated w/ the deficiency of the S-adenosylmethionine that acts as endogenous anti-depressant. A lot of people consume a lot of methionine through their typical diet. In pregnancy, lower intake is associated w/ neural tube defects on newly born babies. Deficiency in methionine (in salmonids primarily) leads to the reduced growth rate w/ development of the bilateral cataracts. Cystine deficiencies and zinc can also be a cause of cataract.
Also, vitamin A and riboflavin deficiencies also contribute in causing this lesion. Deficiency of methionine causes our liver to metabolize histidine only and results in the incomplete form of the folic acid. Deficiency in methionine can also cause loss of hair pigmentation, apathy, lethargy, edema, liver damage, fat and muscle loss, skin lesions, slower growth in children and weakness. This is why its in male extra.
Toxicity, Interactions, Side effects, and Contraindications
An excess intake of methionine without adequate folic acid, Vitamin B12 and B6 intake can increase the methionine conversion to homocysteine. Homocysteine is a blood fat that is potentially harmful and had been linked to the hardening of arteries or atherosclerosis. Supplementation for L-methionine must be avoided if you have elevated levels of homocysteine or if you have the neoplastic disease. If you have a coronary heart disease then you must take it with caution. Supplementation for L-methionine must be avoided by women who are pregnant or nursing unless a physician prescribed it. There are no drugs or interactions with nutrients that are known to be associated with methionine.
Atherosclerosis or the artery hardening: There are concerns that atherosclerosis might be worsened by methionine. It can increase the levels of blood with the homocysteine chemical especially to people with low folate and Vitamin B6 and 12 in their bodies or with people that are having trouble in processing the homocysteine. Too much of it is linked to a higher risk of heart and blood vessel diseases.
Liver diseases such as cirrhosis: The liver disease might be worsened by methionine.
Deficiency of Methylene tetrahydrofolate reductase or MTHFR: This disorder is inherited. This disease changes our body’s way of processing the homocysteine. If you have this disorder, you shoult not take supplements for methionine as it can cause the buildup of homocysteine. Too much of it can increase your chance of developing heart diseases or blood vessel diseases.